Acetaminophen/dextromethorphan/guaifenesin/pseudoephedrine

This classification denotes a combination drug defined by the U.S. Department of Veterans Affairs in its (VA's) National Drug File (NDF) which falls under VA Drug Class RE514. This VA Drug Class (RE514) classifies this compound as belonging to the group DECONGESTANT/ANTITUSSIVE/EXPECTORANT/ANALGESIC. The first component of this combination drug is an analgesic and antipyretic with the molecular formula C8H9NO2, a preparation that US FDA recognizes as an active ingredient or moiety under Unique Ingredient Identifier 362O9ITL9D, chemically known as n-(4-hydroxyphenyl)acetamide but more generally known as acetaminophen, which bears U.S. National Institutes of Health Compound Identifier 1983. Acetaminophen comes in many forms, including base, acetate, cysteine, cysteinylglycine, di-methyl derivative, glucuronide, glutathione, hemisuccinate, mercapturate, and sulfate. The European Medicines Agency schedules Acetaminophen in its eXtended EudraVigilance Medicinal Product Dictionary or XEVMPD under Index SUB09611MIG. The World Health Organization schedules acetaminophen in its Anatomical Therapeutic Chemical (ATC) Classification. The second component of this combination drug is an opioid receptor agonist and opioid with the molecular formula C18H25NO, a preparation that US FDA recognizes as an active ingredient or moiety under Unique Ingredient Identifier 7355X3ROTS, chemically known as 2h-10,4a-iminoethanophenanthrene, 1,3,4,9,10,10a-hexahydro-6-methoxy-11-methyl- but more generally known as dextromethorphan, which bears U.S. National Institutes of Health Compound Identifier 3008. The European Medicines Agency schedules Dextromethorphan in its eXtended EudraVigilance Medicinal Product Dictionary or XEVMPD under Index SUB07051MIG. The term DEXTROMETHORPHAN is an International Non-Proprietary Name. The World Health Organization schedules dextromethorphan in its Anatomical Therapeutic Chemical (ATC) Classification. The third component of this combination drug is an expectorant with the molecular formula C10H14O4, a preparation that US FDA recognizes as an active ingredient or moiety under Unique Ingredient Identifier 495W7451VQ, chemically known as 1,2,3-propanetriol, ether with 2-methoxyphenol but more generally known as guaifenesin, which bears U.S. National Institutes of Health Compound Identifier 3516. The European Medicines Agency schedules Guaifenesin in its eXtended EudraVigilance Medicinal Product Dictionary or XEVMPD under Index SUB07973MIG. The term GUAIFENESIN is an International Non-Proprietary Name or INN (see World Health Organization INN reference publication, Volume 25 , No. 10 1971, List 11). The World Health Organization schedules guaifenesin in its Anatomical Therapeutic Chemical (ATC) Classification. The fourth component of this combination drug is an alpha-adrenergic agonist with the molecular formula C10H15NO, a preparation that US FDA recognizes as an active ingredient or moiety under Unique Ingredient Identifier 7CUC9DDI9F, chemically known as 1s,2s-(+)-pseudoephedrine hydrochloride but more generally known as pseudoephedrine, which bears U.S. National Institutes of Health Compound Identifier 5032. The European Medicines Agency schedules Pseudoephedrine in its eXtended EudraVigilance Medicinal Product Dictionary or XEVMPD under Index SUB10157MIG. The term PSEUDOEPHEDRINE is an International Non-Proprietary Name or INN (see World Health Organization INN reference publication, Volume 19 1975, List 5). The World Health Organization schedules pseudoephedrine in its Anatomical Therapeutic Chemical (ATC) Classification.